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        Poziotinib研究進展
        
                
        
                發(fā)布日期：2017-10-31                                                  瀏覽次數：0
                
        

        核心提示：a href=https://www.medchemexpress.com/Poziotinib.htmlPoziotinib/a產品描述：Poziotinib(NOV120101; HM781-36B) is an irreve
                                        
        
    
    
        
        
            <a   href="https://www.medchemexpress.com/Poziotinib.html">Poziotinib</a>產品描述：Poziotinib(NOV120101;   HM781-36B) is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for   HER1/HER2/HER4 respectively.IC50 value: 3/5/23 nM(HER1/HER2/HER4) [1]Target:   pan-HER inhibitorin vitro: The IC50 levels of HM781-36B for N87 and SNU216   were 0.001 and 0.004 μmol/L, respectively, which was 10–1000 fold lower than   the IC50 levels of other HER family TKIs. HM781-36B more potently inhibited   the phosphorylation of HER family and downstream proteins, and induced   apoptosis and G1 arrest compared to gefitinib or lapatinib [1]. HM781-36B is   a potent inhibitor of EGFR in vitro, including the EGFR-acquired resistance   mutation (T790M), as well as HER-2 and HER-4, compared with other EGFR   tyrosine kinases inhibitors (erlotinib, lapatinib and BIBW2992). HM781-36B   treatment of EGFR DelE746_A750-harboring erlotinib-sensitive HCC827 and EGFR   L858R/T790M-harboring erlotinib-resistant NCI-H1975 NSCLC cells results in   the inhibition of EGFR phosphorylation and the subsequent   deactivati<br><br><br><span style="outline:   0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網點遍及全球20多個國家地區(qū)。MCE經過多年努力已成為全球生物活性小分子領域的一流供應商，   產品涵蓋癌癥、神經科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE 對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE 定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">數千種產品在上海有充足備貨，24-48小時內送達客戶；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family:   "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">大量產品提供免費試用裝；</span><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產品鏈接：<a   href="http://www.medchemexpress.cn/poziotinib.html">www.medchemexpress.cn/poziotinib.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;"   src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   alt="">
        
        
            

        

        
                                                
         
        
                

        


        

         
        

        

        
    
    
         
        

        
        

        

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